Upregulation of PPAR�Ž�³ mediates the antidiabetic effects of citrus flavonoids in type 2 diabetic rats.

Author(s): Ayman M Mahmoud*, Osama M Ahmed, Adel Abdel-Moneim, Mohamed B Ashour

Abstract

Type 2 diabetes mellitus is a complicated metabolic disease characterized by impairment of both insulin secretion and insulin sensitivity. The present study was hypothesized to assess the effect of citrus flavonoids on adipose tissue PPARγ, adiponectin and resistin. Diabetes was induced by feeding rats with high fat diet for 2 weeks followed by an intra-peritoneal injection of STZ (35 mg/kg body weight). An oral dose of 50 mg/kg hesperidin or naringin was daily given for 4 weeks after diabetes induction. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin was decreased. Both hesperidin and naringin administration significantly reversed these alterations. Moreover, supplementation with either compound significantly ameliorated the declined adipose tissue PPARγ and adiponectin expressions in conjunction with down-regulated resistin expression. These experimental findings demonstrated that hesperidin and naringin exhibit antidiabetic effects by modulating adipose tissue genes.

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