Study of the protective effect of fortified wheat grass with cow urine in experimentally induced parkinsonism

Author(s): Sandhya Ch.*, Sampath Kumar G.V.

Abstract

Parkinson’s disease (PD) is neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta which innervates the dorsal striatum. Since the existing anti Parkinson’s drugs encountered many side effects and need for prolonged treatment including questionable efficacy in the treatment, may cause Parkinson related movement problems, hallucinations and orthostatic hypotension. These reasons force the area of research to find improved treatments which will counteract the side effects and the draw backs of the existing treatment. Herbal drugs having diversified uses are always an alternative option to the synthetic drugs which are well known for their side and adverse effects. Using haloperidol induced catalepsy and muscle rigidity in rats the effects of Fortified Wheat grass (FWG) were studied. Haloperidol was administered at a dose of 1mg/kg; Fortified wheat grass with cow urine was administered at doses 150mg/kg & 300mg/kg. In conclusion fortified wheat grass with cow urine at doses of 150 and 300 mg/kg exhibited significant anti cataleptic activity, significantly reversed the haloperidol inhibited locomotor activity, restored the changes in behavioral assessment like akinesia, immobility in haloperidol administered rats, reduced the haloperidol induced rigidity. The possibility of pharmacological interactions between haloperidol and fortified wheat grass with cow urine should be further investigated in my research work.

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