STUDY OF LIPID PEROXIDATION AND SERUM ASCORBIC ACID LEVELS AS INDICES OF OXIDATIVE STRESS IN VARIOUS LUNG DISORDERS

Author(s): Ivvala Anand Shaker*, Suresh Babu Kondaveeti, Hemraz Palwan, Dabburu Kumaraswamy, Raja G, S Saleem Basha

Abstract

The present study was planned to assess the levels of oxidant and antioxidant in various lung disorders and to evaluate the existence of correlation between oxidant-antioxidant levels. Asthma, Bronchitis, COPD and Lung fibrosis well know chronic inflammatory disorders where disturbances in the oxidative system have been observed. To investigate the lipidperoxidation in terms of plasma MDA and antioxidant capacity in terms of ascorbic acid (Vitamin C) were measured. Results revealed statistically significantly Increase serum MDA (P<0.001) and decrease vitamin C (P<0.001) in patients suggestive of oxidative imbalance in various lung disorders was revealed. However there is negative correlation between lipidperoxidation and ascorbic acid levels correlation. The study thus supported the emerging concept of free radical injury in various lung disorders and therefore a thought can be given to whether antioxidant supply could have a beneficial impact on the free radical induced injury and improvement of respiratory reserve in various lung disorders.

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