STABILITY STUDY OF MEMORIN CAPSULE BY THIN LAYER CHROMATOGRAPHIC AND HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD AS A QUALITY CONTROL TOOL FOR AYURVEDIC FORMULATION

Author(s): Shital D Sankpal*, Ashish K Mullani, Shrinivas K Mohite and John I D’ Souza

Abstract

Since last one decade India has seen tremendous growth in herbal drug market, which has resulted in development of numerous proprietary herbal drug formulations by various manufacturers, majority of them comprising of polyherbal formulations. With the advancement of knowledge in the field of phytochemistry it has now been observed that many of these constituents present in the drug may react with each other raising the serious concern about the stability of such formulations. This is the area, which needs to address in order to determine the efficacy of the formulation. Stability testing of herbal products is a challenging task, because the herbal product is regarded as the active substance, regardless of whether constituents with defined therapeutic activity are known. The purpose of the stability testing is to provide proof of how the quality of the herbal products varies with the time under the influence of environmental factors such as temperature and humidity. Different parameters were checked at regular intervals. These studies are conducted at 40°C. If any significant change occurs at any time during six months, testing at the accelerated storage condition should be conducted and evaluated against significant change criteria by various analytical methods such as TLC and HPTLC. Therefore evaluation of the parameters based upon chemical, physical, microbiological, therapeutic studies can serve as an important tool in stability studies.

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