SPECTROPHOTOMETRIC DETERMINATION OF CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE USING �?¢�?�?��?�?MULTIWAVELENGTH SPECTROSCOPIC METHOD�?¢�?�?��?

Author(s): Arun Kumar Kaura, Ravinder Sharma, Monika, Parveen Bansal and Rakesh Chawla

Abstract

With the help of UV Spectrophotometer a rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropanolamine Hydrochloride (PPM) by “Multi wavelength Spectroscopy” has been developed in combined pharmaceutical dosage forms. The proposed method was successfully applied for the determination of drugs in physical mixture and commercial formulations. The earlier methods developed for simultaneous determination of Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride in combined pharmaceutical dosage forms were expensive and time consuming, so these studies may serve as a basis for simultaneous analysis of CPM and PPM in combined pharmaceutical dosage forms having results of good linearity, precision and reproducibility.

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