Sonochemical synthesis of 2,4-disubstituted quinolines catalyzed by phosphosulfonic acid (PSA) under solvent-free conditions

Author(s): Jhansi Rani Vangavaragu, Kothari SathishBabu, Nanda Kumar Yellapu, Anindita Chatterjee*

Abstract

A simple, efficient and environment-friendly one-pot multicomponent method has been developed for synthesizing 2,4-disubstituted quinolones. It uses ultrasound-mediated condensation of aldehydes, alkynes and amines in the presence of various catalysts under solvent-free conditions. Phosphosulfonic acid (PSA)was found to be superior to other catalysts for the reaction of 2-methoxybenzaldehyde and ethynylbenzene with 4-methoxyaniline.A series of 2,4-disubstituted quinolines were synthesized in good to excellent yields after short reaction times when compared to the conventional thermal method.Thisnew procedure provides several advantages over current methods, including: simple work-up, cost effectiveness, a wide range of functional group tolerance and use of an inexpensive reusable heterogeneous catalyst. All new compounds were identified and characterized by 1H,13C NMR and HRMS spectra.

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