Serum Endothelin-1 as biomarker in oral cancer - a case control study

Author(s): Sumaiya Irfan*, Nishi Tandon, A.N.Srivastava, Richa Sharma, Vijay Kumar

Abstract

Worldwide, cancers of the oral cavity and pharynx are the 6th most common type & it is a major problem in the Indian subcontinent. Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Serum Endothelin-1 level have been studied in various human cancers like colon & breast. To evaluate significance of serum Endothelin in oral cancer we undertook a case control study. A total of 48 subjects 24 controls and 24 oral cancers were enrolled for the study. Serum Endothelin-1 levels were evaluated by ELISA. The results showed that there was significant difference in serum Endothelin-1 levels in oral cancer and control. Therefore we conclude that serum Endothelin -1 has a potential role as a serum marker for oral cancer progression.

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