ROLE OF TGF BETA AND IL-18 PROMOTER POLYMORPHISM IN ASSOCIATION WITH LUNG CANCER

Author(s): Khadeer Basha Shaik, Hema Prasad M, Lakshmi Velaga, G Sudhakar and Swarupa R Didla

Abstract

Lung cancer is the number one cause of cancer-related deaths in the world. World Health Organization classified it into two main histological groups such as non-small cell lung cancer and small-cell lung cancer. Its incidence is highly correlated with cigarette smoking, among the 10% of patients who develop it without a smoking history, the environmental or inherited causes of this is usually unclear. These are most predominant as the cancer is a multistep, progressive disease and early chromosomal changes provide the cell with proliferative advantage. The role of TGF beta in association with pulmonary tumorigenesis and inhibition is a hallmark of multiple cancers including lung cancer. Restoration of this TGF beta signalling reduces tumorigenicity in human lung cancer cells. The present study undergone to assess the role of TGF beta and IL-18 promoter polymorphism in association with lung cancer by molecular and cytogenetic studies in lung cancer patients. The results were compared with the healthy population series. It was found that the recessive allele "T" in TGF Beta and A/A frequency at the position -607 of IL 18 is considerably and significantly higher in patients. There were no abnormalities derived from the cytogenetic study.

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