QUALITY STANDARDIZATION AND TOXICITY STUDY OF GARLICON A CARDIOVASCULAR FORMULATION
Author(s): Shirke Madhuri Arun, Magdum Chandrakant S, Patki Shalaka R and Disouza John I
Abstract
Herbal medicines have long therapeutic history and still serving the needy. However the quality standardization and toxicity study of herbal medicines still remains a challenge because of complex nature of phyto-constituents and therefore it is difficult to establish standard and quality control profile for raw material as well as finished product. Most of the medicines are effective but one major drawback is lack of standardization. So, there is a need to develop a standardization technique and toxicity study according to guidelines to come together this system of medicine in the main stream of health science. The main objective of this study was to perform standardization and toxicity study of a polyherbal formulation i.e. “Garlicon tablet” which contains Garlic (Alium Sativum), Arjuna Ghan (Terminalia Arjuna), Nagarmotha powder (Cyperus Rotundus), Shuddha guggul (Commiphora Mukul), Awala Ghan (Emblica Officinalis), Dalchini powder (Cinnamomum Zeylanicum) The formulation used to treat cardiovascular diseases. It was standardized on the basis of organoleptic characters, phytochemical screening, and physico-chemical, microscopical, analytical parameters. The set parameters were found to be sufficient for the quality control/quality assurance purposes. The Garlicon formulation was also subjected for acute and sub-acute study. Toxicity study for Garlicon indicated that it was a safe polyherbal formulation and free from any toxic effect. Thus it can be concluded that the Garlicon was found to be well-tolerated by rats. Acute and sub-acute oral toxicity studies in rats using the highest attainable dose of 2000 mg/kg did not cause any lethal effect.
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