PREVALENCE OF VITAMIN D DEFICIENCY IN TYPE-2 DIABETES MELLITUS PATIENTS AND ITS CORRELATION WITH GLYCEMIC CONTROL

Author(s): Mukherjee Brijesh and Patra Saurav

Abstract

Vitamin D and its active metabolite, 1, 25-di (OH)-vitamin D or calcitriol, have long been recognized as important regulators of serum calcium and bone health. Production of calcitriol is dependent on adequate vitamin D. Following constitutive conversion of vitamin D to 25(OH)-vitamin D by the liver, most circulating calcitriol (hormonal calcitriol) is made by the highly regulated 1alpha-hydroxylase (CYP27B1) present in the kidneys. Numerous other tissues also possess 1alpha-hydroxylase and appear to produce calcitriol locally at high concentrations. The receptor for calcitriol, the vitamin D receptor (VDR), is expressed in virtually all tissues. A large proportion of the population has low vitamin D levels, which are generally defined as a serum level of 25(OH)- vitamin D less than 20 or 30 ng/mL. Although sunlight stimulates skin production of vitamin D, many in modern society are dependent on ingestion of vitamin D in milk or supplements to maintain normal vitamin D levels, especially during the winter months. Vitamin D deficiency is particularly common in hospitalized individuals, those with chronic diseases, and African Americans. Over the past decade, the relationship of vitamin D deficiency to the risk of developing diabetes mellitus (DM) and the risk for diabetic complications has been of great interest to scientists. The purpose of this study is to determine vitamin D status among type 2 diabetics in outpatient department of medicine in our hospital and examine the relationship between vitamin D status and level of glycemic control. This study indicates there is a definite negative correlation between Vit D levels and diabetes (r= - 0.94 and -0.97 in Group 1 and 2) and poorly controlled diabetics have further lower values of Vitamin D (p< 0.01 for vit D when compared between Group 1 and Group 2)

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