Positive correlation of genetic transmittance of type 2 diabetes mellitus with anthropometric indices in adults of Majha region of Punjab, India.

Author(s): Neenu Khanna*, Ram Sarup Sharma

Abstract

Family history represents the integration of shared genomic and environment risk factors. First degree relatives (IDRs) share half their genomic information and also behavior, life styles, beliefs, culture and physical environment, so their disease experience may offer a clue to shared susceptibilities. This suggests that a ‘low tech’ clinical approach-family history-might be a practical and useful way to target interventions and disease prevention efforts to those most at risk. Diabetes Mellitus (DM) is an “iceberg” disease seen in all age groups. India shall have the largest number of diabetics by 2030. Anthropometry provides the single most portable, universally applicable, inexpensive and non-invasive technique for assessing the size, proportions and composition of the human body. This study has been conducted to determine whether such abnormalities can be detected in healthy young adults with a family history of type 2 diabetes mellitus at an early age that may presage the onset of this chronic disease. The present study will be the conducted among 200 healthy adults (20-30 years of age) of Amritsar city (100 having family history of type 2 diabetes mellitus and 100 age matched adults serve as control group).The basic anthropometric measurements of height, weight, hip circumference, waist circumference and the derived indices body mass index (BMI), waist hip ratio (WHR) and waist height ratio (WHtR) were determined from these basic measures. The various basic and derived anthropometric indices showed changes in healthy adult offspring of the parents with history of type 2 diabetes mellitus. The results were statistically analyzed by using SPSS Software version 17.0. All the derived anthropometric indices are significantly increased in young healthy adults (20-30yrs of age) having positive family history of type 2 diabetes mellitus.

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