In vitro antioxidative role of Helicteres isora

Author(s): Bilal Ahmad Bhat, C. Elan chezhiyan, S. Sethu pathy

Abstract

Free radicals are implicated for more than 80 diseases including diabetes mellitus, arthritis, cancer, ageing, etc. In treatment of these diseases, antioxidant therapy has gained an utmost importance and research is now directed towards finding naturally occurring antioxidant of plant origin. In a step in this direction we have evaluated antioxidant potency of a plant extract Helicteres isora of four different solvent extracts. But only hexane extract was investigated for its free radical scavenging action towards 1, 1-Diphenyl–2picryl hydrazyl, nitric oxide and superoxides and Reducing assay, FRAP, Total phenolic content etc and found that the hexane extract is having promising free radical scavenging activity in dose dependent manner. This antioxidant potency may be related to the presence of antioxidant vitamins and other compounds present in the extract. These results clearly indicate that it is effective against free radical mediated diseases.

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