FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF ESOMEPRAZOLE

Author(s): Biresh K Sarkar*, Sandeep Singh Tanwar, Prashant Soni, Pratyush Jain

Abstract

The present study involves preparation and evaluation of floating microsphere using Esomeprazole as a model drug for prolongation of the gastric retention time. The microspheres were prepared by the solvent evaporation method using different polymer like Hydroxy Propyl Methyl Cellulose and Methyl Cellulose. The surface morphology of the prepared microsphere was characterized by Scanning Electron Microscopic. In vitro drug release studies were also performed. The objective of the present study was to develop floating microsphere of Esomeprazole in order to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and there by improved bioavailability. The prepared microspheres were evaluated for particle size, in vitro release and incorporation efficiency. The effects of various formulation variables on the size and drug release were also investigated.

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