Evaluation of hepatoprotective activity of aerial parts of Eremurus himalaicus Baker.

Author(s): Sumaira Amin, Z. A. Bhat*

Abstract

The aim of the present study was to evaluate the hepatoprotective activity of methanolic and aqueous extract of Eremurus himalaicus against paracetamol-induced hepatotoxicity. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin. Silymarin was used as positive control. The results of the paracetamol-induced liver toxicity experiments showed that mice treated with methanolic and aqueous extract of E. himalaicus (200 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the paracetamol treated group. The current study confirmed the hepatoprotective effects of methanolic and aqueous extract of E. himalaicus against the paracetamol induced hepatotoxicity.

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