Evaluation of acute toxicity study for Euphorbia hirta..

Author(s): Shirish S. Pingale

Abstract

The present study investigated the acute toxicity of Euphorbia hirta plant material in Swiss mice. The plant material was administered orally at dose ranging from 2gm to 10gm/Kg body weight of the plant material in the form of slurry. The animals were observed continuously for the first 4 hours for any behavior changes and they were then kept under observation up to 14 days after administration of the plant material as drug to find out the mortality. From the observations it is concluded that Euphorbia hirta plant material at doses of 10 g/kg body weight is nontoxic since no marked changes in behavioral, food and water intake were observed. The Euphorbia hirta plant material was found to be safe. No lethality or adverse toxic signs were seen during the experimental study period and during 14 days observation period. No delayed toxic signs were reported in all experimental groups. These findings of this study suggest that the Euphorbia hirta could be relatively safe when administered orally in Swiss mice.

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