Estimation of urea, uric acid and creatinine in pathogenesis of OSMF: a randomized blind trial

Author(s): Deepak Narang* Vanita Rathod; Fatima Khan; Jaideep Sur; Rachita Jain; Dharmen Bhansali; Manish Pandit, Deepak Thakur and Shama Shishodiya

Abstract

Oral Submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the submucosal tissues (lamina propria and deeper connective tissues). Present study is aimed to analyze the serum uric acid, urea, creatinine levels in Oral Submucous Fibrosis patients and compare them with those of healthy controls. Clinical study was conducted from 2014 to 2015 at Rungta College of dental sciences [Bhilai] in each of 20 clinically diagnosed and histopathologically proven patients of OSMF groups (I and II) and twenty normal patients had serum uric acid, urea and creatinine levels measured using spectophotometer. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 19.0 (SPSS19). Statistical significance was determined at P < 0.05. No alteration was observed in serum uric acid, urea and creatinine levels in OSMF patients when compared with normal controls. This study showed that serum uric acid, urea and creatinine were altered in OSMF patients compared with healthy volunteers but were statistically non-significant. These findings suggest that pan masala tobacco users are in a state of alteration in the biochemical parameters promoting cellular damage when comparing with non-tobacco users. However, further prospective cohort studies are suggested to better understand their role in aetiology and progression of OSMF.

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