EFFECT OF ALKALINITY ON CANCEROUS CELLS AT DIFFERENT pH AND MORPHOLOGICAL VARIATIONS IN-VITRO

Author(s): Mohsin Ali Khan, Aparna Misra, Anchal Trivedi and AN Srivastava

Abstract

The acidic environment due to excessive glycolytic activity and poor perfusion promote the cancerous cell growth. This condition also decreases the efficiency of chemotherapeutic drugs. The present study investigates whether alkalinity increment of the media can reduce the cancerous cell growth and improve the effect of chemotherapeutic drugs in-vitro. For this experiment, the vero cells were control whereas MDA-MB and IM cells were experimental cancerous cells. The alkaline pH of media reduces the cancerous cell growth up to 18% to 42%, but the exact mechanism is not known with certainty.

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