DSD: A DATABASE OF SNP ASSOCIATED DISEASES
Author(s): Sameer Chaudhary*, Sapana Mehendale, Shweta Metkar, Tanvee Pardeshi, Akhil Jobby, Vaibhav Kandale, Shama Mujawar and Apurva Patange
Abstract
Single nucleotide polymorphisms, frequently called SNPs, are the most common type of genetic variation among people. They occur normally throughout a person’s DNA and studies show the serious association between SNPs and disease. Substantial data regarding SNPs is available but specific and detailed information regarding SNPs and genes related to particular diseases is either unavailable or has to be gathered from several databases. Unlike other existing SNP databases which fail to produce SNP-disease association or doesn't show related PubMed references or doesn't give details regarding the SNPs etc., DSD is a manually curated database containing information regarding SNPs known to cause many diseases. It is the one stop reference for information related to SNPs where disease can be browsed from a list. Each of the record contains details of SNPs, its related gene name, gene id, gene symbol, mRNA allele and protein residue change, UniProt ID, reference Pubmed articles and NCBI assay ID. This database also contains Gene view, variation view and SNP view to provide user a single platform to retrieve the information related to an SNP associated with that disease. DSD also gives population details. It will be a unique resource to study SNPs related to many diseases and help the scientific community to carry out the fundamental research. In the current release, 371 unique SNP entries are included in which data regarding thirty four types of cancer and five polygenic diseases. The future release of DSD will feature many more diseases such as genetically predisposed, polygenic and autoimmune. The database can be accessed at www.rasadbsnp.com
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