DESIGN AND EVALUATION OF ROSIGLITAZONE LOADED BIO LIP STRIPS FOR TRANSLABIAL DRUG DELIVERY

Author(s): Satheesh Madhav NV and Abhay Pratap Yadav

Abstract

Rosiglitazone is an oral hypoglycemic agent which undergoes extensive first pass metabolism and having extremely short halfâ�?�??�?�?��?�??�?life which make it a possible candidate for delivery through skin. The aim of this study was to explore the potentiality of lip skin as a novelistic platform due to its unique histology by formulating Rosiglitazone loaded lip strip using a novel bio material which was isolated from pulp of artocarpus heterophyllus by simplified economical process. Rosiglitazone loaded bio lip strips were formulated by using artocarpus heterophyllus biomaterial as a strip former and dextrose as a flexicizer. The formulated strip was subjected for various evaluation parameters like moisture content, folding endurance, swelling index, stability studies, in-vitro and in-vivo release. Our results revealed that the Rosiglitazone release was extended over a period of 24 hrs. This was confirmed by the in-vitro release data. Release kinetics of bio strips followed Higuchi model and the mechanism of the drug release was diffusion and anomalous type. The results are expressed as mean ± SEM values. Statistical significances were evaluated using t test. A value of p<0.05 was considered significant. The best formulation was selected on the basis of various evaluated parameters, linearity of drug diffusion rate and used concentration of biomaterial in the formulation. The formulated strips are feasible for delivering Rosiglitazone through Translabial route.

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