Changes in biochemical markers of renal function in subclinical and overt hypothyroidism

Author(s): Vaneet Kaur*, Kamaljit Singh, Minni Verma

Abstract

The present study aimed to determine whether thyroid dysfunction has deleterious effects on renal function. Both renal function tests (urea, creatinine and uric acid) and thyroid function tests (TSH, fT3 and fT4) were conducted in 100 patients with euthyroid status and 50 patients with subclinical and overt hypothyroidism respectively. A statistically significant rise in the levels of urea and creatinine has been observed in patients with subclinical and overt hypothyroidism as compared to euthyroid subjects. Also, a positive correlation been observed between the rise in TSH levels and creatinine in patients with overt hypothyroidism. A statistically significant rise in uric acid levels has been observed in patients with overt hypothyroidism as compared to controls. These observations are suggestive of monitoring the renal function in patients with hypothyroidism.

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