Assessment of severity and patterns of adverse drug reactions of antitubercular drugs used in dots therapy

Author(s): Shashi Marko*, J. L. Marko

Abstract

Adverse drug reactions (ADRs) are considered as one among the leading causes of morbidity and mortality. A general knowledge of the various ADRs and their management is essential for the effective management of Tuberculosis. This study was planned for assessment of severity and patterns of ADRs to Anti-tubercular drugs used in DOTS therapy in Hamidia Hospital, Bhopal and T.B. Hospital Idgah Hills, Bhopal. Information of the ADRs is data based collected from DOTS center with the help of treating physician and other health care professionals in a specialized Performa and the assessment of ADRs done with the help of various scales and investigations. Maximum numbers of ADR were reported among male population within 4 week of starting DOTS therapy. Gastrointestinal system (Gastritis) was the most common system affected followed by Skin (Rashes). Majority of ADRs 53.22% were moderate, and 46.77% were mild. No severe life threatening ADRs were observed during the study period. In our study, we found DOTS therapy safer, but regular monitoring is required for ADRs to prevent the ADRs at the initial stage.

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