ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITY OF METHANOLIC EXTRACT OF CINNAMOMUM TAMALA (NEES) IN EXPERIMENTAL ANIMAL MODELS

Author(s): Thamizhselvam N*, Soumya S, Sanjayakumar YR, Salinichandran K, Venugopalan TN, Jaya N

Abstract

This study was aimed to evaluate the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of Cinnamomum tamala leaves. Materials and Methods: Anti-inflammatory activity was studied in Swiss albino mice using carageenan. Analgesic activity was evaluated in mice by using hot plate method, acetic acidinduced writhing movement and tail flick test. Antipyretic activity was evaluated by using brewer’s yeast. Result: The study showed that C. tamala extract was having anti-inflammatory activity at the different test doses. The analgesic activity was also found to be significant (p<0.05) and dose dependent prolongation of response latency in the hot plate test. Acetic acid induced writhing assay showed the decreased number of stretching episodes in the extract treated groups. The antipyretic assay revealed the temperature-decreasing pattern significantly (p<0.01) when compared with control. Conclusions: These results demonstrated that Cinnamomum tamala has potential health benefits as it can produce significant anti-inflammatory, analgesic and antipyretic activities.

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