Amelioration of arsenic induced meiotic chromosomal abnormalities by Psidium guajava (guava) in Mus musculus.

Author(s): Andalib Iqbal*, Dharmshila Kumari

Abstract

Arsenic trioxide (0.04 mg/animal/day) when administered orally to Albino Swiss mice (Mus musculus) for 15 days increased the frequency of abnormality 112 (37.33%±2.11) compare to 28 (9.33%±2.59) of control in meiotic chromosome. The abnormality was 22 (7.33%±2.39) in group fed only with guava fruit extract. However, when guava fruit extract and Arsenic trioxide fed concurrently the abnormality was 68 (22.66%±2.69) respectively. The result showed that arsenic trioxide is potent enough to damage meiotic chromosome and present finding also showed that concurrent treatment of guava fruit extract and arsenic trioxide minimize the frequency of meiotic chromosomal abnormalities. Therefore, it is suggested that the guava extract may reduce the risk of arsenic induced genotoxicity.

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