Cover Image

Seroprevalence of leptospirosis in Chennai city, India.

Padma Kumari J.*, Sheila Doris T., Usha Krishnan K.


Leptospirosis is a zoonotic disease, it occurs worldwide but is most common in tropical and subtropical countries. The magnitude of the problem varies from community to community. The serovars which cause the disease in a community change with adaptation to a new maintenance host and is epidemiologically important. Aims and Objectives: To determine the seroprevalence of leptospirosis in Chennai city. To identify the prevalent serovar in Chennai causing leptospirosis by using gold standard test Microscopic Agglutination Test (MAT). Methods: 1209 patients from Chennai, with fever of one-week duration and with signs and symptoms of Leptospirosis were the study population and were screened for Leptospirosis by Macroscopic Slide Agglutination Test (MSAT). The positive samples by MSAT were tested for the prevalent serovar and for confirmation by MAT and the results were analyzed statistically. Result: The seroprevalence of Leptospirosis is 17.8%. The prevalent serovar circulating in Chennai is L. grippotyphosa. Conclusion: Laboratory diagnosis is essential to confirm the current illness, and for epidemiological and public health reasons, namely to determine which serovar caused the infection, the likely source of infection and the potential reservoir and its location. This helps in control strategies.


Leptospirosis; MSAT; MAT; seroprevalence; serovar

Full Text:



Betty A. Forbes. Sahm Alice S. Weissfeld Bailey and Scott’s Diagnostic Microbiology, Edi:12, Pg 539-54.

Nwafor Okoli.C, S.Kularatne, C.Gamage, R.Rajapaske, Y.Obayashi, and H. Tamashiro. Leptospirosis among community-based rural residents in Kandy, Sri Lanka: Implications for intervention. International Journal of Infectious Diseases, , Volume 14,Supplement 1, 2010-03-01 Pages e390-e390.

Dutta T K, M Christopher. Leptospirosis An Overview.J Assoc Physicians India. (April 2005), 53:545-51

Sharma.S, P. Vijayachari, A P. Sugnan, K. Natarajaseenivasan, A. C Sehgal 2006, Seroprevalenceof Leptospirosis among high-risk population of Andaman Island, India, Am J Trop Med. Hyg. ; 74(2) (2006) pg 278-283.

Sumathi G, KS Chinari Pradeep and S. Shiva Kumar .MSAT – A screening test for Leptospirosis. Indian J Med Microbiol (1997) – 15: 84.

Effler, P. V.;A.K. Bogard.; H.Y.Domen.; A.R.Katz.; H.Y.Higa. &D.M. Sasaki. ."Evaluation of eight rapid screening tests for acute leptospirosis in Hawaii." J Clin Microbiol 40(4):(2002) 1464-9.

WHO (2011).Mapping of Neglected Tropical Diseases in the South-East Asia RegionIn:CommunicableDiseaseNewsletter,20.08.2011,Availablefrom:

Gangadhar, N. L.; K Prabhudas, ; S. Bhushan, ; M.Sulthana, ;S.B. Barbuddhe, &H. Rehaman,. "Leptospira infection in animals and humans: a potential public healthrisk in India." Rev Sci Tech 27(3): (2008). pg 885-92.

Sharma K K, A Gururajkumar, A Mohan, V.Sivakumar,U Kalawat. A preliminary study on the prevalence of leptospira serovars among suspected cases of leptospirosis at Tirupati, Andhra Prades.IJMM, Vol 24, Issue 4(2006), page 302.

Harrison’s Principle of Internal Medicine Vol-1 18th edition pg 1392-1398.

Noor Rafizah.A.A, Y.N.Azwany, M.Kamarul Imran., A. Mohamed Rusli., S.Mohd Nazri., A.Mohd Nikman., I.Nabillah., H.SitiAsma.,W.M.Zahiruddin., I.Zaliha –A hospital – based study on seroprevalence of leptospirosis among febrile cases in northeastern Malaysia. International Journal of Infectitious Diseases. Vol 17, Issue 6(,June 2013) pages e394 – e397.

.Leptospirosis Laboratory Manual, Regional Medical Research Centre: Port Blair, Andaman 2013.

Muthusethupathi MA, S.Shivakumar , M.Jayakumar S.Rajendran .Acute Renal Failure in Madras city. Changing profile. Ind J Nephrology (New series) (1993); 3:66.

Muthusethupathi MA, Shivakumar S, Jayakumar M,Renal involvement in leptospirosis – our experience in Madras City. Journal of Postgraduate Medicine vol: 40 Issue: 3(1994) Pg 127-31.

Chinari Pradeep KS. A two year study on serodiagnosis ofLeptospirosis. The Tamil Nadu Dr. M.G.R. Medical University, March 1998.

Prabhakar PK, BN Harish, RS Rao . Seroprevalence of leptospirosis among febrile and jaundice patients. Indian J Med Microbiology (1995); 13:189-91.



  • There are currently no refbacks.

Copyright (c) 2016 International Journal of Bioassays

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

International Journal of Bioassays is a member of the Publishers International Linking Association, Inc. (PILA), CROSSREF and CROSSMARK (USA). Digital Object Identifier (DOI) will be assigned to all its published content.