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Evaluation of antidiabetic activity of an important medicinal plant Aloe cim-sheetal leaf extract on streptozotocin induced diabetic rats

Chandra Sekhar Singh B.*, Surekha M., Rama Rao B., Roja Rani A.


Diabetes mellitus belongs to the group of metabolic diseases characterized by hyperglycemia and defective protein metabolism. This study was undertaken to study the antidiabetic effect of the methanol extract of Aloe CIM- Sheetal (CAL 14) on streptozotocin induced diabetic rats. Diabetes was induced experimentally in fasted SD rats (170-180gm) by intra-peritoneal injection of STZ at a dose of 55 mg/kg b.w. and leaf extract of Aloe: control rats received (0.4 ml of 0.1 M of cold citrate buffer). Diabetic rats treated with Glibenclamide (0.60mg /kg) decreased blood glucose level from 298.66 ± 2.16 mg/dl to 192.00 ± 4.14 mg/dl (58.94%). Diabetic rats treated with Aloe 300 mg/kg showed decreased blood glucose levels from 299.16 ± 1.94mg / kg to 190.00 ± 7.61 mg/kg (52.86 %) at the end of 21st day indicating that blood  glucose  levels was significantly (P ≤ 0.05) decreased compared to diabetic control groups. The sub-acute toxicity study of methanol leaf extract of Aloe does not produce any significant toxicity symptoms in body weights and histological changes were observed in pancreas, liver and kidney. These data suggest that Aloe CIM- Sheetal leaf extract have ameliorative hypoglycemic effect and could be a useful source of an antidiabetic agent.


Aloe CIM-Sheetal; fasting blood glucose; Diabetes mellitus; Streptozotocin; herbal medicine.

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