Cover Image

A study on amlodipine induced gingival hyperplasia

Shan Sasidharan*, Jisha Sara John, Jisha Sara John, Bhagya Prasad, Bhagya Prasad, Anil Babu, Anil Babu, Seethadevi B., Seethadevi B.


Amlodipine is a calcium channel blocker which has main action on vascular smooth muscles. It blocks L-type calcium channels and causes vasodilatation. Gingival hyperplasia is a rare adverse effect of amlodipine which can happen in 1-10%cases. A 53 year old male patient was found to have gingival hyperplasia after treating with amlodipine as add-on therapy for hypertension.


Amlodipine; adverse drug reaction; chronic kidney disease; gingival hyperplasia.

Full Text:



Taib H, Ali TBT, Kamin S. Amlodipine-induced gingival overgrowth: a case report. Archives of Orofacial Sciences, 2007 2, 61-64.

Ellis JS, Seymour RA, Thomason JM, Monkman SC andIdle JR, 1993. Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet, 341: 1102-1103.

Hallmon WM and Rossmann JA, 1999. The role of drugs in the pathogenesis of gingival overgrowth. A collective review of current concept. Perio 2000, 21:176-196.

Jorgensen MG, 1997. Prevalence of Amlodipine-Related Gingival Hyperplasia. J. Periodontol, 68: 676-678.

Lacy CF, Armstrong LL, Goldman MP, Lance LL. Lexi-comp’s drug reference handbook. 15th edition. Lexi-Comp. Canada. 2007. Page no: 110.

Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale’s Pharmacology. Churchill and Livingstone. 2007

Tripati KD. Essentials of medical pharmacology. Sixth edition. Jaypee brothers medical publishers (p) ltd. New Delhi. 2006.

Lafzi A, Farahani RMZ, Shoja MAM. Amlodipine-induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal, 2006, 11:E480-2.

Grover V, Kapoor A, Marya CM. Amlodipine Induced Gingival Hyperplasia. J Oral Health Comm Dent 2007, 1 (1): 19-22.

Marshall RI, Bartold PM. A clinical review of drug-induced gingival overgrowth. Oral Surg Oral Med Oral Pathol, 1993; 76:543-548.



  • There are currently no refbacks.

Copyright (c) 2015 International Journal of Bioassays

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

International Journal of Bioassays is a member of the Publishers International Linking Association, Inc. (PILA), CROSSREF and CROSSMARK (USA). Digital Object Identifier (DOI) will be assigned to all its published content.