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Clinical profile of pancytopenia: a tertiary care experience

Bhagwan Singh Yadav*, Amit Varma, Priyanka Kiyawat

Abstract


This study was done to document the clinico-hematological profile of pancytopenia in adult patients. A total of 53 cases of pancytopenia were diagnosed during the period of Jan 2012 to Dec 2012. Full blood count was performed in all the cases. Clinical variables were recorded for each patient. Out of 53 cases 29 were male. The mean age of patients was 35.15±12.6 years. Pallor and fever were the main presenting symptoms. The main etiological cause of pancytopenia in our case series was megaloblastic anaemia followed by septicaemia and alcoholic and non-alcoholic liver disease. Early identification of the underlying conditions would help in understanding the disease process, and early planning for further investigations and management will enhance survival rate of a case with pancytopenia.

Keywords


Pancytopenia; Megaloblastic anemia; Septicemia; Leukemia; Aplastic anemia

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References


Hayat AS, Khan AH, Baloch GH, Shaikh N. Pancytopenia; study for clinical features and etiological pattern of at tertiary care settings in Abbottabad. Professional Med J 2014; 21(1): 060-065.

Naseem S, Varma N, Das R, Ahluwalia J, Sachdeva US, Marwaha RK. Pediatric patients with bicytopenia/pancytopenia: Review of etiologies and clinic hematological profile at a tertiary centre. IJPM 2011; 54(1):75-80.

Rahim F, Ahmad I, Islam S, Hussain M, Khattak TAK, Bano Q. Spectrum of hematological disorders in children observed in 424 consecutive bone marrow aspirations/biopsies. Pakistan Journal of Medical Sciences 2005; 21(4):433-436.

Ng SC, Kuperan P, Chan GL. Megaloblastic anemia- a review from University Hospital, Kuala Lampur. Ann Acad Med Sing. 1988; 17:261.

Imbert M, Scoazec JY, Mary JY, Jouzult H, Rochant H, Sultan C. Adult patients presenting with pancytopenia: A reappraisal of underlying pathology and diagnostic procedures in 213 cases. Hematol Pathol 1989; 3:159-67.

Savage DG, Allen RH, Gangaidzo IT, Levy LM, Gwanzura C, Moyo A, et al., Pancytopenia in Zimbabwe. Am J Med Sci 1999; 317:22-32.

Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone marrow examination in cases of pancytopenia. J Nepal Med Assoc 2008; 47:12-7.

Ayub T, Khan FR. Prevalence of megaloblastic anaemia in a paediatric unit. Gomal J Med Sci 2009; 7:62-4.

Memon S, Salma S, Nizamani MA. Etiological spectrum of pancytopenia based on bone marrow examination by children. J Coll Physicians Surg Pak 2008; 18:163-7.

Varma N, Dash S. A reappraisal of underlying pathology in adult patients presenting with pancytopenia. Trop Georg Med 1992; 44:322-7.

Kumar R, Kabra SP, Kumar H, Anand AC, Madan H. Pancytopenia - a six year study. J Assoc Phys India 2001; 49:1078-81.

Tilak V, Raini J. Pancytopenia-a clinico-hematological analysis of 77 cases. Indian J Pathol Microbiol 1999; 42:399-404.

Khunger JM, Arunselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia- a clinico-hematological analysis of 200 cases. Indian J Pathol Microbiol 2002; 45:375- 9.

Bhatnagar SK, Chandra J, Narayan S, Sharma S, Singh V, Dutta AK. Pancytopenia in children: Etiological profile. J Trop Pediatr 2005; 51:236-9.

Gupta V, Tripathi S, Tilak V, Bhatia BD. A study of clinico-haematological profiles of pancytopenia in children. Trop Doct 2008; 38:241-3.

Gayathri BN, Rao KS. Pancytopenia: A Clinico Hematological Study. J Lab Physicians. 2011; 3(1): 15–20.

Knodke K, Marwah S, Buxi G, Vadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Academy Clin Med 2001; 2:55-9.

Mussarrat Niazi, Fazl-i-Raziq. The incidence of underlying pathology in pancytopenia- An experience of 89 cases. Year JPMI; 18(1): 76-79.

Fauzia Shafi Khan, Rabiya Fayyaz Hasan. Bone marrow examination of pancytopenic children. J Pak Med Assoc 2012; 62 (7): 660-662.




DOI: http://dx.doi.org/10.21746/ijbio.2015.01.0014

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