Cover Image

Estimation of serum magnesium and zinc levels in type 2 diabetes mellitus

Jaswant Kaur*, Tajinder Singh

Abstract


Diabetes mellitus is chronic disease characterized by defective insulin production or utilization. Type-2 diabetes mellitus has mainly peripheral insulin resistance as a cause with or without insulin secretary defects. In particular, type-2 diabetes mellitus has been shown to be associated with abnormalities in the metabolism of Zinc, Chromium, Magnesium and Manganese. The serum levels of Zinc and Magnesium are usually low in diabetic patients. The study finding may exhibit the extent of deficiencies of these two trace elements in relation to duration of the disease. It may be utilized to optimize the control of type-2 diabetes mellitus by supplementation of zinc and magnesium. By doing so the metabolic complications of diabetes mellitus can be delayed.

Keywords


Serum Magnesium; Serum Zinc; Type 2 diabetes mellitus

Full Text:

PDF

References


Quilliot D et al., Evidence that diabetes mellitus favor impaired metabolism of zinc, copper, selenium in chronic pancreatitis. Pancreas: 2001; 22 (3):299-306.

Wokoma FS. Diabetes and hypertension in Africa, an overview. Diabet Int 2002; 12:36-40.

Unwin N, Sobngwi E, Albert KGMM. Type-2 diabetes: the challenge of preventing a global epidemic. Diabet Int 2001 11:3-8.

Glaser E, Halpern G. Insulin action. Biochem 1929; 207:377-83.

Mertz W. Effects and metabolism of glucose tolerance factor Nutr Rev 1975; 3:129-35

Vincent JB. Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev 2000; 58:67-72.

Murray RK, Granner PA, Rodwell VW. Metabolism of carbohydrates. In: Harpers Biochemistry, 25th. Appleton and Lange, 2000:190-5.

Kruse-Jarres JD, Rukgauer M. Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells. J Trace Elem Med Bio 2000; 14:21-7.

Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998; 17:109-15.

Suarez Z. Decreased insulin sensitivity in skeletal muscle of hypomagnesemic rats. Diabetologia 1993; 36:82.

Resnick LM et al., Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study. Hypertension 1991; 17:951-7.

Trinder P. Determination of Glucose in blood using glucose-oxidase with an alternative oxygen acceptor. Annals Clinical Biochemistry 1969; 6: 24-27

Saito M, Makino T. Estimation of zinc in serum by colorimetric assay. Clin Chimica Acta 1998; 120: 127-35.

Bohuon C. Determination of magnesium level in serum by colorimetric method. Clin Chimica Acta 1962; 7: 811-17.

Goldstein DE, Little RR, Weidmayar HM. Glycated hemoglobin: methodologies and clinical applications. Clin Chem 1986; 32: B64-70

Zargar AH et al., Copper, zinc and magnesium levels in type-1 diabetes mellitus. Saudi Med J 2002; 23:539-42.

Al-Maroof RA, Al-Sharbatti SS. Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type-2 diabetics: Saudi Med J 2006; 27:344-50.

Anetor JI, Senjobi A, Ajose OA, Agbedana EO. Decreased serum magnesium and zinc levels: artherogenic implications in type-2 diabetes mellitus in Nigerians. Nutr Health 2002; 16:291-300.

Schmits Chek HF, Rempis R. Prevalence of Hypomagnesaemia in an unsealed German population of 16,000 individuals. Magnes Res. 2001; 14: 283-290.

Ashima B, Kuldip SS, Rajesh P, Jasbir S. Serum magnesium level: A key issue for diabetes mellitus. Journal of JK Science 2011;13,3:132-134

Sharma A et al., Serum magnesium: an early predictor of course complications of diabetes mellitus. J Indian Med Assoc 2007.105:16-20.




DOI: http://dx.doi.org/10.21746/ijbio.2015.01.009

Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 International Journal of Bioassays

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

International Journal of Bioassays is a member of the Publishers International Linking Association, Inc. (PILA), CROSSREF and CROSSMARK (USA). Digital Object Identifier (DOI) will be assigned to all its published content.