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Evaluation of thyroid dysfunction in patients suffering from diabetes mellitus in a tertiary care hospital

Tajinder Singh*, Jaswant Kaur


Diabetes mellitus is an endocrine disorder so it is prone to affect other endocrine functions, one of which is thyroid function. The present study was conducted to estimate thyroid hormone levels in diabetes mellitus (Both type 1, type 2) and to compare these levels with normal population (control). Fasting blood samples from 50 diabetic subjects (7 type 1 and 43 type 2) and 50 non diabetic control were analysed. Out of the 50 diabetic patients for the study, 21 are males (3 in type1 and 18 in type 2) and 29 are females (4 in type 1 and 25 in type 2). Of these 31(62%) are euthyroid, 7 (14.0%) had primary hypothyroidism (6females and 1male),1(2.0%) had primary hyperthyroidism(only 1male), 9(18%)  had  subclinical hypothyroidism (1male and 8 females), 2(4.0%) had subclinical hyperthyroidism(1male and 1female). Maximum cases were of hypothyroidism (subclinical and clinical) seen in the study group. There were only 2 subjects in control groups having thyroid disorders. So thyroid disorders in study group is highly significant as compared to control group. As the level of Glycosylated Hb (HbA1c) increases the chances of thyroid disorders also increases. There is high prevalence of thyroid disorders in diabetes. Thyroid disorders are more common in females and most common thyroid disorder is hypothyroidism. The association of thyroid disorders are more frequent in diabetics who have deranged metabolic control. 


Thyroid hormones; Type 1 DM; Type 2 Diabetes Mellitus Glycosylated Hb.

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John HK, Peter HF. Basic and clinical Endocrinology: Greenspan FS, Baxter JD, 4th, Lange Medical. Stamford. 1994; 580

Pamela CC, Richard AH, Denise RF. Lippincott illustrated reviews: Pamela CC, Richard AH, 4th, Wolters Kluwer. Philadelphia: 2008; 337

Daniel WF. Principles of Internal Medicine: Anthony SF et al., 14th. The McGraw-Hill Companies, Inc, 1998; 2060

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33: S62-S69

Feely J, Isles TE. Screening for thyroid dysfunction in diabetics. British Medical Journal,1979; 1: 1678 n

Gray SR, Irvine JW, Clarke FB. Screening for thyroid dysfunction in diabetics. British medical journal,1979; 2: 1439

Hage M, Zantout SM, Azar TS. Thyroid disorders and diabetes mellitus. Journal of thyroid research 2011

Trinder P. Determination of Glucose in blood using glucose-oxidase with an alternative oxygen acceptor. Annals Clinical Biochemistry 1969; 6: 24-27

Goldstein DE, Little RR, Weidmayar HM. Glycated haemoglobin: Methodologies and clinical applications. Clin Chem 1986; 32: B64-70

Bal BS, Kaur PP, Singh MB, Singh G, Singh PS. Prospective analysis of thyroid abnormalities in cases of Type 2 diabetes mellitus. J Assoc Phys India 2003; 51: 1165

Bharadiya Amit A et al., Evaluation of thyroid function tests in patients with uncontrolled type 2 diabetes mellitus: International J of Health Science and Research. 2014; 4(5): 129-138

Palanisamy P, Govindaswamy B, Ganesan S, Ramachandran S. Screening for thyroid dysfunction in diabetic/ Non diabetic population. Journal of thyroid science 2008; 3(8)

Rajan SK, Ezhilarasi A, Sasidharan M. Thyroid dysfunction in patients with Type 2 diabetes mellitus. J Assoc Phys India 2003;51: 1229

Bharat et al., Thyroid status in diabetes mellitus. J Glycomic & Lipidomics 2013, 3:1

Cardoso MF, Ohwovoriole AE, KuKu SF. A study of thyroid function and prevalence of thyroid autoantibodies in an African diabetic population. J Diabetes Complications 1995; 9: 37-41

Chubb SA, Davis WA, Inman Z, Davis TM. Prevalence and progression of subclinical hypothyroidism in woman with type 2 diabetes: the Fremantle Diabetes Study. Clin Endocrinol (oxf) 2005; 62: 480-86

Ranabir S. Thyroid dysfunction in type 2 diabetes mellitus: A retrospective study. Indian j Endocr Metab 2012; 16, Suppl S2: 334-5.



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