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Study of upper gastrointestinal changes in chronic kidney disease

Mohit Goyal, Shiv Charan, Santokh Singh, Sumit Pal Singh Chawla*, Ravinder Garg, Sarabjot Kaur


Chronic Kidney Disease (CKD) is defined as the presence of objective kidney damage or Glomerular Filtration Rate (GFR) of 60ml/min/1.73m2 or less, for at least 3 months, irrespective of the underlying etiology of kidney damage. It results in various complications involving virtually every system of the body. Gastrointestinal (GI) complications are known to occur commonly in patients with CKD. In this study, 100 patients of CKD stage 3-5 (GFR <60 ml/min/1.73m2) were evaluated for presence of any upper GI lesions, using Upper Gastrointestinal Endoscopy (UGIE) so as to guide for early preventive and therapeutic strategies. 86% of total patients studied had one or more upper GI lesions; gastritis, esophagitis and gastric ulcer being the most prevalent lesions. These lesions are more common in advanced stages of CKD. The symptoms due to these lesions can markedly affect the quality of life and contribute to increased rates of malnutrition among CKD patients. Recognition of their presence, early diagnosis and management of these upper GI lesions can reduce morbidity and mortality in CKD patients.


Chronic kidney disease; upper gastrointestinal lesions; upper gastrointestinal endoscopy, gastrointestinal complications; gastritis; oesophagitis

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