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Anticancer activity of Acanthus illicifolius linn. From chettuva mangroves, Kerala, India

Smitha R. B.*, Madhusoodanan P. V., Prakashkumar R.

Abstract


Mangroves are salt-tolerant plants of tropical and subtropical intertidal regions of the world. In spite of the commercial properties, mangroves are used in folklore medicine. The main objective of the present study is to identify the anti-cancer activity of Acanthus illicifolis (Acanthacea), used in folklore medicine for the treatment of several diseases. The present study was aimed at using leaf and root extract as anticancer agent. The ethyl acetate extract was treated under various concentrations in MCF-7 and PA-1 cell lines. The results showed that at 100 μg/mL, the leaf extracts showed 99.8±0.2 and 100±0 percentage of inhibition on MCF-7 cell lines and 99.9±0.2 and 100±1 on PA-1 cell lines. The CC 50 values clearly indicated the anticancer activity of Acanthus illicifolius.

Keywords


Acanthus illicifolis L.; Ethyl acetate; Cytotoxicity; MCF-7; PA-1

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DOI: http://dx.doi.org/10.21746/ijbio.2014.11.004

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