Cover Image

A comparative study of serum magnesium in type 2 diabetes mellitus patients and non-diabetics and its correlation with glycemic status

Mamatha B. V.*, Shankarprasad D. S., Manjula R.


Diabetes mellitus (DM) is a heterogeneous group of metabolic disorders characterized by chronic hyperglycemia. Diabetes mellitus is the major healthcare problem worldwide. The metabolism of several minerals has been reported to alter in diabetes mellitus and these elements might have specific roles in the pathogenesis and progress of this disease. Of these minerals magnesium is the important one. Magnesium is a cofactor in phosphorylation of glucose, and it helps in carbohydrate metabolism. Hypomagnesaemia is a common feature in patients with type 2 DM and has been proposed as a risk factor for type 2 DM. Studies on this parameter have been done in many other countries but very few in India. Hence a study was conducted to estimate and compare the levels of serum magnesium in newly diagnosed uncomplicated type 2 DM patients and healthy controls. A case control study was conducted on 79 patients with clinically diagnosed type 2 DM and age and sex matched 79 apparently healthy subjects as controls from the general population. Blood samples were analyzed to estimate fasting blood sugar (FBS), postprandial blood sugar (PPBS), serum magnesium and glycated hemoglobin (HbA1c) levels in both cases and controls. The data was analyzed and expressed in terms of mean ± SD. Pearson correlation was performed to establish  the  relationship  between the study  variables. There was a statistically significant decreased level of serum magnesium (p < 0.0001) in cases. There was a highly significant negative correlation between serum magnesium and HbA1c.


Fasting blood sugar; HbA1c; Post prandial blood sugar; Serum Magnesium; Type 2 DM

Full Text:



Park K, Epidemiology of chronic non communicable diseases, 21st Edition, Bhanot Publishers, 2011: 362.

Colin Dayan, Gareth Williams. Disorders of glucose homeostasis. In: David A. Warrell, Timothy M. Cox, Jhon D. Firth editors. Oxford Textbook of Medicine. 5th edition. New York: Oxford; 2010. P. 2003.

John B. Buse, Kenneth S. Polonsky, Charles F. Brunnet. Type 2 diabetes mellitus. In: Kronenberg, Melmed, Polonsky, Larsen editors. Williams Textbook of Endocrinology. 12th edition. Philadelphia: Saunders Elsevier; 2011. P. 1371-73.

Farid SM, Abulfaraj TG. Trace mineral status related to levels of glycated hemoglobin of type 2 diabetic subjects in Jeddah, Saudi Arabia. Medical Journal of Islamic World Academy of Sciences 2013; 21(2): 47-56.

Xu J, Xu W, Yao H, Sun W, Zhou Q, et al., Associations of Serum and Urinary Magnesium with the Pre-Diabetes, Diabetes and Diabetic Complications in the Chinese Northeast Population. PLoS ONE 2013; 8(2): e56750.

Seyoum B, Siraj ES, Saenz C, Abdulkadir J. Hypomagnesemia in ethiopians with diabetes mellitus. Ethnicity & Disease 2008; 18: Spring.

Lott JA and Turner K. Evaluation of Trinder’s Glucose Oxidase Method for Measuring Glucose in Serum and Urine. Clin. Chem1975: 21(12):1754-60.

Baginski ES, Marie SS, Karcher RE, Zak B. Selected methods of Clinical Chemistry 1982; 9:277.

Burtis A, Ashwood R, Bruns E, editors. Estimation method for magnesium. Teitz textbook of clinical chemistry and molecular diagnostics, 5th edition. New Delhi: 2012. p 1751-1755.

Masood Naila, Baloch Ghulam Hussain, Ghori Rafi Ahmed, Memon Iqbal Ahmed, Anwar Muhammad and Memon Muhmmad Sadik. Serum Zinc and Magnesium in Type 2 Diabetic patients. J Coll Physicians Surg Pak. 2009; 19(8): 483-486.

Lecube A, Baena-Fustegueras JA, Fort JM, Pelegrı´D, Herna´ndez C, et al., Diabetes Is the Main Factor Accounting for Hypomagnesemia in Obese Subjects. PLoS ONE 2012; 7(1): e30599.

Badyal A, Sodhi KS, Pandey R, Singh J. Serum Magnesium Levels:A Key Issue For Diabetes Mellitus JK SCIENCE 2011;Vol. 13(3).

Seyoum B, Siraj ES, Saenz C, Abdulkadir J. Hypomagnesemia in ethiopians with diabetes mellitus. Ethnicity & Disease 2008; Volume 18: Spring.

Chambers EC, Heshka S, Gallagher D, Wang J, Pi-Sunyer FX, Pierson RN. Serum Magnesium and Type-2 Diabetes in African Americans and Hispanics: A New York Cohort. Journal of the American College of Nutrition 2006; Vol. 25(6): 509–13.

Ankush RD, Suryakar AN and Ankush NR. Hypomagnesaemia in type-2 diabetes mellitus patients. A study on the status of oxidative and nitrosative stress. Indian Journal of Clinical Biochemistry 2009; 24 (2): 184-9.

Anjum A, Yousaf M, Zuber M, Ahmad HB, Zahoor AF. Comparative study on calcium, magnesium and cobalt in diabetic and non-diabetic patients (males) in Punjab, Pakistan. AJB 2012; 11(28): 7258-62.

Shaikh MK, Devrajani BR, Soomro AA, Ali Shah SZ, Devrajani T and Das T. Hypomagnesemia in Patients with Diabetes mellitus. World Applied Sciences Journal 2011; 12 (10): 1803-6.

Monika K. Wälti, Michael B. Zimmermann, Giatgen A. Spinas, Richard F. Hurrell. Low plasma magnesium in type 2 diabetes. Swiss Med Wkly 2003; 133:289–92.



  • There are currently no refbacks.

Copyright (c) 2014 International Journal of Bioassays

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

International Journal of Bioassays is a member of the Publishers International Linking Association, Inc. (PILA), CROSSREF and CROSSMARK (USA). Digital Object Identifier (DOI) will be assigned to all its published content.