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Simultaneous spectrophotometric estimation of phenylpropanolamine hydrochloride (ppm) and chlorpheniramine maleate (CPM) using “simultaneous equation method (vierodt’s method)”

Arun Kumar Kaura*, Ravinder Sharma, Dr. Monika, Jagmohan Sharma

Abstract


With the help of UV Spectrophotometer a rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropanolamine Hydrochloride (PPM) by Simultaneous Equation Method (Vierodt’s Method)has been developed in combined pharmaceutical dosage forms. The proposed method was successfully applied for the determination of drugs in physical mixture and commercial formulations. The earlier methods developed for simultaneous determination of Chlorpheniramine Maleate and Phenylpropanolamine Hydrochloride in combined pharmaceutical dosage forms were expensive and time consuming, so these studies may serve as a basis for simultaneous analysis of CPM and PPM in combined pharmaceutical dosage forms having results of good linearity, precision and reproducibility.

Keywords


Derivative; UV absorption; spectral overlap; principle maxima; wavelength range; analytical signal

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DOI: http://dx.doi.org/10.21746/ijbio.2014.10.0015

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