Cover Image

Association of thyroid-stimulating hormone and thyroid hormones with lipid profile in ghanaian euthyroid patients with type 2 diabetes

Nii Ayite Aryee*, Emmanuel Ayitey Tagoe


Increasing evidence suggests that thyroid stimulating hormone (TSH) may exert extra-thyroidal effects and modulate the profile of blood lipids.  The aim of this study was to determine the association between TSH levels, thyroid hormones, thyroxine (FT4), free triiodothyronine (FT3) and lipid profile in euthyroid type 2 diabetic and non-diabetic subjects with elevated cholesterol levels.   Serum levels of TSH, FT4 and FT3 in diabetic and non-diabetic euthyroid subjects with normal and elevated cholesterol levels were assayed.  Total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL-c) cholesterol were also analyzed.  Serum TSH levels were found to be lower in individuals with elevated cholesterol.  Serum TSH levels correlated positively with TC, LDL-c and HDL-c but showed a negative relationship with TG and FPG in diabetics with elevated cholesterol. FT3 showed negative correlation with lipid parameters and FPG except HDL-c. However, serum FT4 levels were not significantly different between study groups.  We infer that TSH may be one of many biochemical modulators of circulatory lipids.  Our results suggest that reduction in TSH levels may play a role in the elevation of lipids irrespective of diabetic status.  An assessment of TSH status may have wide-ranging clinical significance in the management of hypercholesterolemia in both diabetic and non-diabetic individuals.


Thyroid Stimulating Hormone (TSH); Management

Full Text:



Mullur R, Yan-Yun L, Brent GA, Thyroid hormone regulation of metabolism, Physiological Reviews, 2014, 94, 355-382.

Limbu YR, Rai SK, Ono K, Lipid profile of adult Nepalese population, Nepal Medical College Journal, 2008, 1, 4-7.

Zhu X, Cheng SY, New insights into regulation of lipid metabolism by thyroid hormone, Current Opinion in Endocrinology, Diabetes and Obesity, 2010, 17(5), 408–413.

Klein I, Ojamaa K, Thyroid hormone and the cardiovascular system, New Engl J Med 2001, 344(7), 501–509.

Biondi B, Klein I, Hypothyroidism as a risk factor for cardiovascular disease, Endocrine, 2004, 24(1), 1–13.

Biondi B, Kahaly GJ, Cardiovascular involvement in patients with different causes of hyperthyroidism, Nature Reviews Endocrinology, 2010, 6(8), 431–443.

Chubb SA, Davis WA, Davis TM, Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations. The Fremantle diabetes study, J Clin Endocrinol Metab, 2005, 90 (9), 5317-5320.

Roos A, Bakker SJL, Links TP, Gans ROB, Wolffenbuttel BHR, Thyroid function is associated with components of the Metabolic Syndrome in Euthyroid Subjects, J Clin Endocrinol Metab, 2007, 92, 491-496.

Garduno-Garcia JJ, Alvirde-Garcia U, Lopez-Carrasco G, Padilla-Mendoza ME, et al., TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects, Eur J Endocrinol, 2010, 163, 273–278.

Wang F, Tan Y, Wang C, Zhang X, Zhao Y, Song X, et al., Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones, J Clin Endocrinol Metab, 2012, 97, 2724-2731.

Ruhla S, Weickert MO, Arafat AM, Osterhoff M, Isken F, Spranger J, et al., A high normal TSH is associated with the metabolic syndrome, Clin Endocrinol, 2010, 72, 696-701.

Pallas D, Koutras DA, Adamopoulos P, Marafelia P, Souvatzoglou A, Piperingos G, et al., Increased mean serum TSH in apparently euthyroid hyper cholesterolemic patients. Does it mean occult hypothyroidism?, J Endocrinol Invest, 1991, 14, 743–746.

Tagoe EA, Azasu H, Annan DA, Ababio GK, Asare-Anane H, Aryee NA, Evaluation of thyroid profile in Ghanaian patients with Type 2 diabetes, Int J Adv Res, 2014, 2(4), 602-609.

Kim BJ, Kim TY, Koh JM, Kim HK, Park JY, Lee K, et al., Relationship between serum free T4 (FT4) levels and metabolic syndrome (MS) and its components in healthy euthyroid subjects, Clin Endocrinol, 2009, 70, 152-160.

World Health Organization, WHO consultation report, Definition, diagnosis and classification of diabetes and its complications, 1999, WHO Geneva.

Friedewald WT, Levy RI, Fredrickson DS, Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, 1972, 18, 499–502.

Sawant AM, Shetty D, Mankeshwar R, Ashavaid TF, Prevalence of dyslipidemia in a young adult Indian population, JAPI, 2008, 56, 99-102.

Toruner F, Altinova AE, Karakoc A, Risk factors for cardiovascular disease in patients with subclinical hypothyroidism, Adv Ther, 2008, 25, 430-437.

Gordon L, Ragoobirsingh D, St Errol YA, Morrison EYA, Choo-Kang E, McGrowder D, et al., Lipid profile of type 2 diabetic and hypertensive patients in the Jamaican population, J Lab Physicians, 2010, 2(1), 25–30.

Singh G, Gupta V, Sharma AK, Gupta N, Evaluation of Thyroid Dysfunction among type 2 diabetic Punjabi Population, Adv. Biores, 2011, 2(2), 3-9.

Wanjia X, Chenggang W, Aihong W, Xiaomei Y, Jiajun Z, Chunxiao Y, et al., A high normal TSH level is associated with an atherogenic lipid profile in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart disease, Lipids Health Dis, 2012, 11, 44.

Pasupathi P, Bakthavathsalam G, Ganesan-Saravanan G, Sundaramoorthi S, Screening for thyroid dysfunction in the diabetic/non-diabetic population, Thyroid Science, 2008, 3(8), 1-6.

de Greef WJ, Rondeel JM, Heide R, Klootwijk W, Visser TJ, Is thyrotropin-releasing hormone immunoreactivity in peripheral blood an estimate for hypothalamic thyrotropin-releasing hormone release?, Acta Endocrinol (Copenh), 1992, 126(3), 276-81.

Suzuki J, Nanno M, Gemma R, Tanaka I, Taminato T, Yoshimi T, The mechanism of thyroid hormone abnormalities in patients with Diabetes mellitus, Nippon Niabunpi Gakki Zasshi, 1994, 7, 465-470.

González-Rodríguez LA, Felici-Giovanini ME, Haddock L, Thyroid Dysfunction in an Adult Female Population: A population-based study of Latin American Vertebral Osteoporosis Study (LAVOS) - Puerto Rico Site, P R Health Sci J, 2013, 32(2), 57–62.

Menon VU, Sundaram KR, Unnikrishnan AG, Jayakumar RV, Nair V, Kumar H, High prevalence of undetected thyroid disorders in an iodine sufficient adult South Indian population, J Indian Med Assoc, 2009, 107(2), 72-77.



  • There are currently no refbacks.

Copyright (c) 2014 International Journal of Bioassays

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

International Journal of Bioassays is a member of the Publishers International Linking Association, Inc. (PILA), CROSSREF and CROSSMARK (USA). Digital Object Identifier (DOI) will be assigned to all its published content.