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Antimicrobial activity of tio2 nanoparticles against microbial isolates causing dental plaques

Anitha Thomas*, Shailaja Raj M., Jagirdar Venkataramana


The mouth is a favorable habitat for a great variety of bacteria due to presence of nutrients, epithelial debris and secretions. Dental plaque is a soft deposit that accumulates on the teeth. The buildup of dental plaque on teeth is a normal physiologic process, occurring in both healthy mouths with cavities or gum disease. A study was carried out to isolate microorganisms from patients with dental problems. 40 samples were collected from Savitha dental clinic, Hyderabad, indicated the presence of both bacteria and fungi. The antimicrobial activity of Titanium dioxide nanoparticle was checked against all these organisms responsible for plaque formation and among these 40 dental isolates titanium dioxide nanoparticles showed antimicrobial activity against 18 isolates and comparatively high zone of inhibition against isolates like D2, D5, D14, D19, D23. The antimicrobial activity of Isopropanol as control, Titanium dioxide, and Titanium dioxide nanoparticle was comparatively analyzed and results shows that TiO2 nanoparticles showed highest activity and the Minimum inhibitory concentration was found to be 15 mg /ml.   


Antimicrobial activity; Dental plaques; Nanoparticles; Titanium dioxide.

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