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Significance of seroprevalence of hepatitis b in HIV positive patients

Sureena Chouhan, Geeta Parihar, Seema Srivastava*


Study was undertaken to find out the significance of the co-infection of HBV/ HIV. HBV/HIV co-infection is a growing public health concern because both the diseases spread in a similar way. This co-infection has an increased risk of fibrosis and cirrhosis. Out of 256 samples 12 samples were positive for HBV i.e. 4.68% positivity. Highest prevalence was found among age group 36-45  years (50%), while not a single HBV positive case were recorded in less than 15 years of age. 6 out of 12  patients were between of 36-45 year of age, which implies that HBV infection is more common in adults. These observations will help the health professionals to deal better with HBV & HIV co-infected patients and will reinforces the need of prevention programs, which also lead to reduction in prevalence of HBV in HIV infected patients.


Seroprevalence; HIV-HBV co-infection; cirrhosis; fibrosis

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Alter MJ, Epidemiology of viral hepatitis and HIV co-infection. J. Hepatol. 2006: 44 (1 suppl): S6-9.

Benhamou Y, Hepatitis B in the HIV co-infected patients. JAIDS 2007; 45/ suppl 2): S57-S65 and S66-S67).

Blumberg BS, Alter HJ & Visnich S, A "new" antigen in leukemia sera. J. Amer. Med. Ass. 191:541-6, 1965. [Institute for Cancer Research, Philadelphia, PA and NIH, Bethesda, MD]

Bodsworth NJ, Cooper DA, Donovan B, The influence of human immunodeficiency virus type 1 infection on the development of the hepatitis B virus carrier state .J infect Dis 1991; 163: 1138-1140.

Bodsworth N, Donovan B, Nightingale BN, The effect of concurrent human immunodeficiency virus infection on chronic hepatitis B: a study of 150 homosexual men. J infect Dis 1989 oct; 160(4): 577-82.

Bran N, Fox R, Xiao P et al., Presentation and outcome of hepatocellular carcinoma in HIV infected patients: a US-Canadian Multicentre Study. J Hepatol 2007; 47: 527-537.

Bruix J; Sherman M. Management of Hepatocellular Carcinoma. Hepatology 2005; 42: 1208-1236.

Eskild A, Magnus P, Peterson G et al., Hepatitis B antibodies in HIV infected homosexual men are associated with more rapid progression to AIDS 1992 JUN : 6(6) : 571-4.

Gatanaga H, Yasuoka A, Kikuchi Y, Tachikawa N, Oka S. Influence of prior HIV-1 infection on the development of chronic hepatitis B infection. Eur J Clin Microbiol Infect Dis 2000; 19:237-9.

Gilson RJ, Hawkins AE, Beecham MR, et al., Interaction between HIV and Hepatitis B virus in homosexual men effects on the natural history of infection. AIDS. 1997 Apr; 11(5): 597-606.

Hadler SC, Judson FN, O Malley PM, et al., Outcome of Hepatitis B virus infection in homosexual men and in relation to prior human immunodeficiency virus infection. J infect Dis 1991 Mari 163(3): 454-9.

Konopnicki D, Mocroft, de WS et al., Hepatitis B and HIV: Prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the Euro SIDA Cohort: AIDS 2005; 19: 593-601.

Marcellin P, Pequignot F, Delarocque Astagneau E et al., Mortality related to chronic hepatitis B and chronic hepatitis C in France: evidence for the role of HIV co infection and alcohol consumption. J Hepatol 2008: 48: 200-207.

Miailhes P, Traband MA, Pradat P et al., Impact of highly active anti retro viral therapy (HAART) on the natural history of hepatitis B virus (HBV) and HIV co-infection : relationship between prolonged efficacy of HAART and HBV surface and early antigen seroconversion. Clin Infect Dis 2007; 45: 624-632.

Opravil M, Hunziker R, Luthy R et al., Chronic hepatitis B and C in HIV infected patients. Deutsche Med Wockeensch 1998 123: 753-760.

Piroth L, Sene D, Pol S, et al., Epidemiology, diagnosis and treatment of chronic hepatitis B in HIV infected patients (EPIB 2005 STUDY). AIDS 2007: 21: 1323-1331

Puoti M, Torti C, Brunol R Filice G, Carosi G. National history of chronic hepatitis B in co-infected patients. J Hepatol 2006; 44 (suppl): S65-S70.

Puoti M, Bruno R, Sorino V, et al., HIV HCC cooperative Italian–Spanish group Hepatocellular carcinoma in HIV infected patients, Epidemiological features, clinical presentation and outcome AIDS. 2004 Nov 19: 18(17): 2285-93.

Sheng WH, Kao JH, Chen PJ et al., Evolution of hepatitis B serological markers in HIV infected patients receiving highly active anti retro viral therapy. Clin Infect Dis 2007; 45: 1221-1229.

Thio CL, Seaberg EC, Skolasky RL et al., HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multi-Center AIDS Cohort Study (MACS). Lancet 2002; 360: 1921-26

Thio CL, Hepatitis B in the human immunodeficiency virus infected patients: epidemiology, natural history and treatment. Semin Liver Dis. 2003 May; 23(2): 125-36.

Thio CL, Hepatitis B and human immunodeficiency virus. Co-infection. Hepatology 2009; 49/suppl): S138-S145.

UNAIDS. 2008 Report on the global AIDS. Epidemic: HIV and AIDS estimates and data 2001 and 2007. Available at http://data pub/globalreport/ 2008/jc1510-2008-global-report-pp211-234-en.pdf (accessed 22 october 2008).

UNAIDS 2008, Report on the global AIDS epidemic, UNAIDS, Geneva, Switzerland.

WHO. Hepatitis B. Fact sheet no. 204 Aug 2008. Available at (accassed 22 october 2008)

Weber R, Sabin A, Fris-Moller N et al., Liver related deaths in persons infected with the human immunodeficiency virus: the D: A: D study, Arch Int Med 2006:166: 1632-1641.



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