Acute anxiolytic effect of ethanolic extract of Saraca asoka bark in wistar albino rats

Chandra shekar Rajan

Abstract


Anxiety is defined as a psychological state characterized by abnormal cognitive, somatic, emotional, and behavioral components. Anxiety is normal reaction to stress. However, when it becomes excessive, falls under the classification of an anxiety disorder. Even though Benzodiazepines (BZDs) are the major class of compounds used in anxiety; long-term use of the same may cause many adverse psychological and physical effects. In the present study, we have attempted to evaluate the acute anxiolytic effect of ethanolic extract of Saraca asoka Bark (EESAB) in Wistar Albino Rats. The rats weighing 150–200gm were divided into 5 groups containing 6 animals for each dose and were housed for 10 days prior to testing. In this study, control (1% Gum acacia), test drug EESAB (100, 200 & 400mg/ kg) and standard drug Diazepam (1.0mg/kg) were administered orally. One hour after oral administration of the drugs / vehicle, the experiment were conducted by Elevated Plus Maze (EPM). Our results suggest that, behavioral dis-inhibitory effects of EESAB exhibited anxiolytic activity at the dose of 200 and 400 mg/kg compared to control.

Keywords


Ashoka bark; Anti-anxiety; Diazepam.

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DOI: http://dx.doi.org/10.21746/ijbio.2013.06.0019

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