Anti-obese therapeutics from medicinal plants-a review

Gude Bujjirao*, Ratnakumar P. K.

Abstract


Obesity is a global health problem. It is also known to be a risk factor for the development of metabolic disorders such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis. Two different obesity-treatment drugs are currently on the market: Orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase; and Sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side-effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. These are mainly complex products having several components with different chemical and pharmacological features. This presented review focused on literature covering natural products with anti-obesity activity, including experimental methodologies, active components, and mechanisms of action against obesity.


Keywords


Obesity; Orlistat; Sibutramine; Pancreatic Lipase

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DOI: http://dx.doi.org/10.21746/ijbio.2013.10.0020

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