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Taurine improves lambda cyhalothrin induced biochemical alterations in Wistar rat liver

Rini Ghosh, Tuhina Das, Anurag Paramanik, Sujata Maiti Choudhury*

Abstract


Taurine is a major intracellular free β-amino acid, which can protect the body against toxicity. Lambda-cyhalothrin, a third-generation type II pyrethroid. is used predominantly in agriculture production and animal husbandry. The aim of the present study was to investigate lambda cyhalothrin-induced biochemical changes in rat liver and to search out the possible role of taurine for the attenuation of hepatotoxic biomarkers.  Male rats were randomly divided into six groups and lambda cyhalothrin was orally administered at two dose levels (10.83mg/body wt., 15.17mg/body wt.) alone and in combination with taurine pretreatment (50mg/kg body wt) for 14 consecutive days. A significant change in blood glucose level with a marked decline in glycogen content were indicated the hepatic dysfunction in lambda cyhalothrin treated rats. This was also confirmed by the altered activities of serum hepatic biomarker enzymes and lipid profiles in LCT intoxicated rats. Pre-treatment of taurine mitigated the abnormalities. These findings pointed out the toxic effect of lambda cyhalothrin in rat liver and also revealed the protective action of taurine against this pyrethroid.

Keywords


Taurine; Lambda cyhalothrin; Blood glucose; Liver glycogen; Serum hepatic biomarker enzymes Lipid profile.

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References


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DOI: http://dx.doi.org/10.21746/ijbio.2016.11.0013

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