Cover Image

Ameliorative effects of gallic acid on cardio-renal complexity induced by isoproterenol

Eman Salah Abdel-Reheim

Abstract


Myocardial infarction (MI) arises out many risk factors, which work in concert and give rise to a lot of unfavorable outcome especially on the kidney. In the present study, we investigate the effect of gallic acid (GA), a natural antioxidant on cardio-renal complexity induced by isoproterenol (ISO). The myocardial infarcted rats showed deterioration in the heart function measured by lactate dehydrogenase (LDH) and creatin kinase (CK) and kidney function measured by urea, uric acid and creatinine. There were relative overweight in both the organs. Abnormal oxidation in lipids of their membrane indicated by the increased malomdialdhyde (MDA) content and nitrite level indicating the increase in their nitric oxide (NO). However, the result indicated a decrease in glutathione (GSH) content and superoxide dismutase (SOD) and peroxidase (POX) activities. These results were assured by other measurements as brain naturetic peptide (BNP) and myoglobin (Mgb) which indicated a damage happened in the myocytes, C-reactive protein (CRP) indicated the inflammatory response and homocystain, angiotensin and aldosterone levels which indicating the kidney hormones secretion. In conclusion, GA ascertained its efficacy in ameliorating the heart function biomarkers, kidney function testes and hormones and oxidation state.

Keywords


Isoproterenol; gallic acid; oxidative stress; cardio-renal complexity

Full Text:

PDF

References


Metra M, Davison B, Bettari L, Sun H, Edwards C, et al., “Is worsening renal function an ominous prognostic sign in patients with acute heart failure? The role of congestion and its interaction with renal function.” Circ Heart Fail. 5, 1 (2012): 54-62.

Cho KH, Shin DG, Baek SH, Kim JR.. “Myocardial infarction patients show altered lipoprotein properties and functions when compared with stable angina pectoris patients.” Exp. Mol. Med. 41, (2009): 67–76.

Frazier L, Vaughn WK, Willerson JT, Ballentyne CM, Boerwinkle E. “Inflammatory protein levels and depression screening after coronary stenting predict major adverse coronary events.” Biol. Res. Nurs. 11 (2009): 163–173.

Stuveling EM, Hillege HL, Bakker S J, Gans RO, De Jong PE, et al., “C-reactive protein is associated with renal function abnormalities in a non-diabetic population.” Kidney Int. 63 (2003): 654–661.

Unger T, Li J. “The role of the renin-angiotensin-aldosterone system in heart failure.” Journal of the Renin-Angiotensin-Aldosterone System 5, S (2004): 57-61.

Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki, Y, et al. “Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.” Nat. Neurosci. 4 (2001): 367–373.

Maxwell SR, Lip GY. "Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic.” Int. J. Cardiol. 58 (1997): 95–117.

Mazzone M, Forte P, Portale G, et al. “Brain natriuretic peptide and acute coronary syndrome.” Minerva Med. 96 (2005): 11-18.

Sorichter S, Puschendorf B, Mair J. “Skeletal muscle injury induced by eccentric muscle action: Muscle proteins as markers of muscle fiber injury.” Exerc. Immunol. Rev. 5 (1999): 5–21.

Bohlmeyer TJ, Wu AHB, Perryman MB. “Evaluation of laboratory tests as a guide to diagnosis and therapy of myositis.” Rheum. Dis. Clin. North Am. 20 (1994): 845–856.

Senaratne MP, Griffiths J, Nagendran J. “Elevation of plasma homocysteine levels associated with acute myocardial infarction.” Clinical and Investigative Medicine 23 (2000): 220-226.

Brattström L, Wilcken DE. “Homocysteine and cardiovascular disease: cause or effect?” Am. J. Clin Nutr. 72, 2 (2000): 315-323.

Ohkawa F, Ikeda U, Kanbe T, Kawasaki K, Shimada K. “Effects of inflammatory cytokines on vascular tone.” Cardiovasc. Res. 30 (1995): 711–715.

Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, et al., “Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells.” Nature medicine 9, 11(2004): 1370-1376.

Suliman ME, Barany P, Kalantar-Zadeh K, Lindholm B, Stenvinkel P, “Homocysteine in uraemia: A puzzling and conflicting story.” Nephrol. Dial. Transpl. 20 (2005): 16–21.

Starkebaum G, Harlan JM. “Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.” Journal of Clinical Investigation 77, 4 (1986): 1370–1376.

Wang B, Zhang Q. “Pacific–East Asian Teleconnection. Part II: How the Philippine Sea Anomalous Anticyclone is established during El Niño Development.” DOI: http://dx.doi.org/10.1175/1520-0442, 2002

Sanchez-Moreno C, Larrauri JA, Saura-Calixto F. “A procedure to measure the antiradical efficiency of polyphenols.” J. Sci. Food Agric. 76 (1998): 270-276.

Prince P SM, Periathambi HP, Devika T. “Gallic acid prevents lysosomal damage in isoproterenol-induced cardiotoxicity in Wistar rats.” Europ. J. Pharmacol. 139 (2009): 139–143.

Abu-Amsha Caccetta R, Burke V, Mori TA, Beilin LJ, Puddey IB, Croft KD. “Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects.” Free Radic Biol Med. 30 (2001): 636–642.

Devi S, Rao MG, Maheswari MU. “Preliminary phytochemical screening of various extracts of Valeriana wallichii root.” V. Sky J. Bioch. Res. 3, 9 (2014): 80 – 85.

Kang MS, Oh JS, Kang IC, Hong SJ, Choi CH. “Inhibitory effect of methyl gallate and gallic acid on oral bacteria.” J. Microbiol. 46 (2008): 744–750.

Kratz JM, Andrighetti-Frohner CR, Leal PC, Nunes RJ, Yunes RA, et al. “Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate” Biol. Pharm. Bull. 31 (2008): 903–907.

Rafieirad M, Chehardacheric SV, Nezhad NN. “Hypolipidemic effects of gallic acid in diabetic rats.” J. Pharm. Biomed. Sci. 32, (2013): 1309-1312.

Kulkarni YA, Addepalli V. “Effect of gallic acid on STZ induced diabetic nephropathy in experimental animals.” FASEB J 24 (2010): 569-565.

Priscilla DH, Prince PSM. “Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.” Chemico-Biological interaction 179, (2–3) (2009): 118–124.

Young DS. “Effects of drugs on clinical laboratory tests.” 3rd ed AACC press (1990): Washington D.C.

Anbarasi K, Vani G, Balakrishna K, Devi CS. “Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of Bacoside A.” Vascular pharmacology. 42, 2 (2005): 57-61.

Leong SF, Lai JCK, Lim L, Clark JB. “The Activities of Some Energy-Metabolising Enzymes in Nonsynaptic (Free) and Synaptic Mitochondria Derived from Selected Brain Region.” J. Neurochem. 42, 5 (1984): 1306-1312.

Bibbins-Domingo K, Coxson P, Pletcher MJ, Lightwood J, Goldman L. “Adolescent overweight and future adult coronary heart disease.” N Engl J Med. 357 (2007): 2371–2379. doi: 10.1056/ NEJMsa073166.

Cartledge S, Lawson N. “Aldosterone and Renin Measurements.” Ann. Clin. Biochem. 37 (2000): 262-278.

Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. “New angiotensins.” J. Mol. Med. 86, 6 (2008): 663‐671.

Hattori Y, Matsumura M, Kasai K. “Vascular smooth muscle cell activation by C-reactive protein.” Cardiovasc. Res. 58, 1 (2003): 186-195.

Kaplan A, Urea. In: Kaplan LA, Pesce AJ. “Clinical chemistry: theory, analysis and correlation.” St. Louis, Miss.: Mosby. (1984): pp. 1257–1260.

Fossati P, Prencipe L, Berti G. “Use of 3,5-dichloro-2-hydroxy-benzenesulfonic acid/ 4-aminophenoazone chromogenic system in direct enzymic assay of uric acid in serum and urine.” Clin. Chem. 26 (1980): 227-231.

Young DS. “Effects of disease on Clinical Lab. Tests” 4th edition, AACC. Press (2001): Washington D.C.

Peters TJ. “Proposal for standardization of total protein assays.” J. Clin. Chem. 14 (1968): 1147-1159.

Doumas BT, Watson WA, Biggs HG. “Determination of serum albumin.” J. Clin. Chem. Acta. 31 (1971): 87-89.

Preuss HG, Jarrel ST, Scheckenbach R, Lieberman S, Anderson RA. “Comparative effects of Chromium vanadium and Gymnema sylvestre on sugar-induced blood pressure elevations in SHR.” J. American Collage of Nutrition 17(1998): 116-123.

James SL, Glaven J. “Macrophage cytotoxicity against schistosomula of schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.” J. Immunol. 134, 12 (1989): 4208-4212.

Kar M, Mishra D. “Catalase, peroxidase and polyphenoloxidase activities during rice leaf senescence.” Plant Physiol. 57(1976): 315-319.

Marklund S, Marklund G. “Involvement of the superoxide anion radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase.” Eur. J. Biochem. 47(1974): 469-474.

Beutler E, Duren O, Kelly BM. “Improved method for the determination of blood glutathione.” J. Lab. Clin. Med. 61 (1963): 882-888.

Vennila L, Pugalendi KV. “Protective effect of sesamol against myocardial infarction caused by isoproterenol in Wistar rats.” Redox rep. 15, 1 (2010): 36-42.

Zaafan MA, Zaki HF, El-Brairy AI, Kenawy SA. “Protective effects of atorvastatin and quercetin on isoprenaline-induced myocardial infarction in rats.” Bull. Fac. Pharm. Cairo Univ. 51 (2013): 35–41.

Mukherjee K, et al. “GPCR-Based Chemical Biosensors for Medium-Chain Fatty Acids.” ACS Synth Biol 4, 12 (2015): 1261-1269.

Akomolafe SF, Ajayi O B. “Aqueous extracts of ripe red pepper and tomato fruits inhibit Fe2+-induced oxidative stress in rat testes and kidney.” Oxid Antioxid Med Sci. 3, 3 (2014): 217-224.

Buttros JB, Bergamaschi CT, Ribeiro DA, Fracalossi AC & Campos RR. “Cardioprotective actions of ascorbic acid during isoproterenol-induced acute myocardial infarction in rats.” Pharmacology 84 (2009): 29–37.

Anker SD, von Haehling S “Inflammatory mediators in chronic heart failure: an overview.” Heart 90 (2004): 464-470.

Ulf-Landmesser MD, Burkhard Hornig MD, Helmut Drexler MD. “A Critical Determinant in Atherosclerosis?” Circulation 109 (2004): II27–II33.

Mehdizadeh R, Parizadeh MR, Khooei AR, Mehri S, Hosseinzadeh H. “Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats.” Iranian journal of basic medical sciences. 16, 1(2013): 56-63.

Umadevi S, Gopi V, Parthasarathy A, Elangovan V. “Ameliorative potential of gallic acid on the activation of ROS and down-regulation of antioxidant enzymes in cardiac tissue of rats infused with advanced glycation end products.” Journal of Applied Pharmaceutical Science 17(2011): 189-193.

Kannan MM, Quine SD. “Ellagic acid inhibits cardiac arrhythmias, hypertrophy and hyperlipidaemia during myocardial infarction in rats.” Metabolism 62, 1 (2013): 52-61.

Firoj A, Siddiqui HH. “Cardioprotective activity of Terminelia Belerica on isoprenaline induced myocardial necrosis in rat.” Asian J. Clin. Pharm. Res. 2, 2(2014): 127-136.

Arya S D, Arora S, Malik S, Nepal S, Kumari S, et al. “Effect of Piper betle on cardiac function, marker enzymes, and oxidative stress in isoproterenol-induced cardiotoxicity in rats.” Toxicol. Mech. Methods 20, 9 (2010): 564-571.

Nagaraja HS, Jeganathan PS. “Forced swimming stress- induced changes in the physiological parameters in albino rats.” Indian J. Physiol. Pharmacol. 43, 1(1999): 53-59.

Sharmila ST. “Rajadurai M, Preventive effect of bio- aq on cardiac markers, lipids and membrane bound enzymes in isoproterenol-induced myocardial infarction in rats.” Asian J. Pharm. Clin. Res. 5, 2 (2012): 107-113.

Nirmala C, Puvanakrishnan R. “Protective role of curcumin against isoproterenol induced myocardial infarction in rats.” Molecular and Cellular Biochemistry 159, 2 (1996): 85–93.

Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, et al. “G Protein–coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.” Circulation 123 (2011): 1953-1962.

Goyal BR, Mehta AA. “Beneficial role of spironolactone, telmisartan and their combination on isoproterenol-induced cardiac hypertrophy.” Acta Cradiologica 67, 2 (2012): 203-211.

Saayi KG. “Protective effect of aegle marmelos L fruit on isoproterenol induced cardiac stress in rats.” Sri Krishnadevaraya University, Shodhganga: a reservoir of Indian theses (2015).

Hirschfield GM, Pepys MB. “C-reactive protein and cardiovascular disease: new insights from an old molecule.” Quarterly J. Med. 96 (2003): 793–807.

Brodde OE. “Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure.” Pharmacological Reviews 43, 2 (1991): 203-242.

Yuko O, Koji F, Hisatomi A, Kiyoshi M, Takuya T, et al. “Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography.” Journal of Hypertension 23, 10 (2005): 1905–1911.

Kumagai H, Sakurai M, Takita T, Maruyama Y, Uno S, et al. “Association of Homocysteine and Asymmetric Dimethylarginine With Atherosclerosis and Cardiovascular Events in Maintenance Hemodialysis Patients.” Am. J.K D. 48, 5 (2006): 797–805.

Yan TT, Li Q, Zhang X, Wu W, Sun J, et al. “Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signaling.” Clin. Exper. Pharmacol. Physiol. 37, 11 (2010): 1071–1077.

Hagar H. “Folic acid and vitamin B12 supplementation attenuates isoprenaline- induced myocardial infarction experimental hyper-homocysteinemic rats.” Pharmacological Research 46, 3 (2002): 213–219.

Leenen FHH, White R, Yuan B. “Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system.” American Journal of Physiology 281, 6 (2001): H2410-H2416.

Zheng FF, Zhu L, Nie A, Li X, Lin J, et al. “Aldosterone-producing adenomas: Clinical characteristics of somatic mutations in chinese patients with aldosterone-producing adenoma.” Hypertension 65 (2015): 622-628.

Kalim MD, Bhattacharyya D, Banerjee A, Chattopadhyay S. “Oxidative DNA damage preventive activity and antioxidant potential of plants used in Unani system of medicine.” BMC Complementary and Alternative Medicine. 10 (2010):77.

Mansouri MT, Farbood Y, Sameri MJ, Sarkaki M, Naghizadeh B, et al. “Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats.” Food Chem, 138, (2–3) (2013): 1028–1033.

Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ, et al. “Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies.” J. Mol. Cell Cardiol. 52, 6 (2012): 1213–1225.

Kang N, Lee JH, Lee W, Ko JY, Kim EA, Kim JS, Heu MS, Kim GH, Jeon YJ. “Gallic acid isolated from Spirogyra sp. improves cardiovascular disease through a vasorelaxant and antihypertensive effect.” Environmental toxicology and pharmacology 39, 2 (2015): 764-772.




DOI: http://dx.doi.org/10.21746/ijbio.2016.10.0010

Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 International Journal of Bioassays

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

International Journal of Bioassays is a member of the Publishers International Linking Association, Inc. (PILA), CROSSREF and CROSSMARK (USA). Digital Object Identifier (DOI) will be assigned to all its published content.