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The chemopreventive role of aged garlic extract against chemically induced tongue carcinogenesis

Hala M. Abdel-Alim*, Hassan Abdel-Dayem, Basem T. Jamal Aboms, Gamal Zuelhemma, Abdelmonein M. Osman

Abstract


Tongue tumors were induced in rats using Diethylnitrosamine (DEN). Aged Garlic extract (AGE) exhibits anticarcinogenic effects. This study aimed to investigate the protective effect (AGE) against DEN induced tongue cancer in rats. Twenty-four Wister rats were divided into 4 groups. In lateral surface of the tongue; Control Groups I and II, received normal saline, while Groups III and IV were injected with 60 mg/kg DENA in a dose of 0.25ml (15mg/rat of 200g). Groups II and IV received pre-treatment with aged garlic extract 250 mg/kg orally daily for 2 weeks. Specimens for clinical and histopathological examinations were retrieved after 3 and 6 weeks. Although clinical and dysplastic histopathological changes were observed in Group 3 and 4, yet, less aggressive features of malignancy were associated with AGE. Better designed study with different doses “DEN and larger samples of animals, are needed to expand the understanding of the chemopreventive effect of AGE as dietary factor to cancer.


Keywords


Aged garlic extract; tongue; Diethylnitrosamine; induced carcinogenesis; Oral cancer; cancer prevention.

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DOI: http://dx.doi.org/10.21746/ijbio.2016.09.009

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