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Characteristics of monitored diabetic patients by glycated haemoglobin (HbA1c)

Tariq A. Zafar

Abstract


Glycated haemoglobin (HbA1c) test indicates the blood glucose levels for the previous two to three months. Using HbA1c test may overcome many of the practical issues and prevent infections such as urinary tract infections (UTIs). The study aimed to evaluate the impact of glycemic control using HbA1c test to understand patient characteristics and UTIs prevalence. Glycemic control was evaluated by measuring HbA1c for a total of 208 diabetes patients who were regularly attending diabetes center in Al-Noor specialist hospital in Makkah.  The results showed that good and moderate glycemic controlled patients were 14.9% and 16.9% respectively while the poor glycemic patients were 68.3%. Among the good improved glycemic control, 83.9% were females, 48.4% were from age group (15-44y). Among the moderately improved glycemic control, 68.4% were females, 54.3% were from age group (45-64 y) with no significant difference. The total number of the patients with positive UTIs was 55 (26.4%) while the total number of patients with negative was UTIs 153 (73.6%). Among the positive UTIs, 76.3% were with poor glycemic control while only 12.3% and 11% were moderate and good improved glycemic control respectively. Among the negative UTIs, 65.3% were with poor glycemic control while only 19% and 15.7% were with moderate and good improved glycemic control respectively.  Prevalence of UTIs among diabetic patients was not significant (p > 0.05). It was concluded that HbA1c was useful monitoring tool for diabetes mellitus and may lead to improved outcomes. Using a HbA1c test may overcome many of the practical issues that affect the blood glucose tests.

Keywords


HbA1c; Diabetes mellitus; glycemic control; Monitoring; patients.

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References


Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, Khalil MZ, Khan NB, Al-Khadra A, Al-Marzouki K, Nouh MS, Abdullah M, Attas O, Al-Shahid MS, Al-Mobeireek A. Diabetes mellitus in Saudi Arabia, Saudi Med J, 2004, 25(11):1603-1610.

American Diabetes Association, Diagnosis and classification of diabetes mellitus. Diabetes Care, 2010, 33(1): S62–S69.

Ahmed AM, History of diabetes mellitus. Saudi Med J, 2002, 23(4):373-378.

Elhadd TA, Al-Amoudi AA, Alzahrani AS. Epidemiology, clinical and complications profile of diabetes in Saudi Arabia: A review. Ann Saudi Med, 2007, 4:241–250.

Chen SL, Jackson SL, Boyko EJ. Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models. J Urol. 2009 Dec. 182 (6 Suppl): S51-6.

International Expert Committee, International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care, 2009, 32:1327–1334.

Reynolds TM, Smellie WS, Twomey PJ; Glycated haemoglobin (HbA1c) monitoring. BMJ, 2006, 16;333(7568):586-588.

Freedman BI, Shihabi ZK, Andries L, Cardona CY, Peacock TP, Byers JR, Russell GB, Stratta RJ, Bleyer, AJ. Relationship between assays of glycemia in diabetic subjects with advanced chronic kidney disease. Am J Nephrol, 2010,31:375-9.

WHO, Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus. Report of a World Health Organization Consultation. Diabetes Res Clin Pract, 2011, 93: 299-309.

American Diabetes Association, Standards of medical care in diabetes. Diabetes Care, 2011, 34 (1): S11-S61.

Alberti KG, Zimmet PZ, Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consulation. Diabetic Medicine, 1998, 15:539-553.

Mostafa SA, Davies MJ, Srinivasan BT, Carey ME, Webb D, Khunti K, Should glycated haemoglobin (HbA1c) be used to detect people with type 2 diabetes mellitus and impaired glucose regulation?. Postgraduate Medical Journal, 2010, 86:656-662

d'Emden MC, Shaw JE, Colman PG, et al., The role of HbA1c in the diagnosis of diabetes mellitus in Australia. Med J Aust, 2012, 197:220–1.

WHO, Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus, Abbreviated Report of a WHO Consultation, 2011, 1-25.

Nkume F A, Chongsi M E, Mbuntum J F, Tanjeko A T, Kwenti T E. Glycemic Control and Urinary Tract Infection in Diabetes Mellitus: A Cross Sectional Study. RRJMHS. 2014; 3 (1): 83-88

Petel JC. Complications in 8793 cases of diabetes mellitus 14 years study in Bombay Hospital, Bombay; India. Indian Med Sci 1989; 43(7): 177-83.

Ophori EA, Imade P, Johnny EJ. Asymptomatic bacteriuria in patients with type-2 diabetes mellitus. JBacteriol Res. 2010;2(suppl 2):14-17.7.

Njunda AL, Assob NJC, Nsagha SD, Nde FP, Kamga FHL, Nkume AF, Kwenti TE. Uropathogens from diabeticpatients with asymptomatic bacteriuria and Urinary tract infections. Sc J Microbiol, 2012, 1(6): 141-146.

Turnpin-Cam-Minkah B, Danso KA, Frimpon EH. Asymptomatic bacteriuria in pregnant women attendingantenatal clinic at KomfoAnokye Teaching Hospital Kumasi Ghana. Ghana Med J, 2007, 41(1):26-29.

Remis RS, Gurwith MJ, Gurwith D, Hargrett-Bean NT, Layde PM. Risk factors for urinary tract infection. Am J Epidemiol, 1987, 126(4): 685-694.

Strom BL, Collins M, West SL, Kreisberg J, Weller S. Sexual activity, contraceptive use, and other risk factors for symptomatic and asymptomatic bacteriuria. Ann Intern Med, 1987, 107:816-823.

Orna Nitzan, Mazen Elias, Bibiana Chazan, and Walid Saliba. Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management. Diabetes Metab Syndr Obes, 2015, 8: 129–136.

Presutti E, Millo J. Controlling blood glucose levels to reduce infection. Crit Care Nurs Q. 2006, 29, (2):123-131.

Van den Berghe G. Insulin therapy in critical illness. Int Diab Monit, 2002, 14 (6):1–6.

Dandona P, Mohanty P, Chaudhuri A, et al. Insulin infusion in acute illness. J Clin Invest, 2005, 115 (8): 2069–2071.

Hirji I, Guo Z, Andersson SW, Hammar N, Gomez-Caminero A. Incidence of urinary tract infection among patients with type 2 diabetes in the UK General Practice Research Database (GPRD) J Diabetes Complications, 2012, 26 (6): 513–516.

Bonora E, Tuomilehto J, The Pros and Cons of Diagnosing Diabetes with A1C. Diabetes Care, 2011, 34(2): S184–S190.




DOI: http://dx.doi.org/10.21746/ijbio.2016.05.006

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